Warfarin-induced tracheobronchial calcification
نویسندگان
چکیده
منابع مشابه
Increased vascular calcification in patients receiving warfarin.
OBJECTIVE Matrix gla protein is a vitamin K-dependent inhibitor of medial arterial calcification whose synthesis and activity are blocked by warfarin. Warfarin induces arterial calcification in experimental models, but whether this occurs in humans is unclear. This was addressed by examining breast arterial calcification, which is exclusively medial and easily identified on mammograms. APPROA...
متن کاملOsteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D.
The present experiments were carried out to test the hypothesis that arterial calcification is linked to bone resorption by determining whether the selective inhibition of bone resorption with osteoprotegerin will inhibit arterial calcification. In the first test, arterial calcification was induced by treating 22-day-old male rats with warfarin, a procedure that inhibits the gamma-carboxylation...
متن کاملWarfarin-induced artery calcification is accelerated by growth and vitamin D.
The present studies demonstrate that growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-carboxylation of matrix Gla protein, a calcification inhibitor known to be expressed by smooth muscle cells and macrophages in the artery wall. The first series of experiments examined the influence of age and growth status on...
متن کاملVitamin K-dependent proteins, warfarin, and vascular calcification.
Vitamin K-dependent proteins (VKDPs) require carboxylation to become biologically active. Although the coagulant factors are the most well-known VKDPs, there are many others with important physiologic roles. Matrix Gla Protein (MGP) and Growth Arrest Specific Gene 6 (Gas-6) are two particularly important VKDPs, and their roles in vascular biology are just beginning to be understood. Both functi...
متن کاملDoes warfarin therapy have a role in coronary calcification?
Some reports have revealed that warfarin inhibits the matrix carboxyglutamic acid protein (MGP), which inhibits calcification. Treatment of rats with warfarin at doses that inhibit the carboxylation of MGP causes rapid calcification of elastic lamellae of arteries and of aortic heart valves and increased expression of MGP-mRNA in the calcifying artery. Therefore warfarin use might result in inc...
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ژورنال
عنوان ژورنال: Indian Journal of Vascular and Endovascular Surgery
سال: 2015
ISSN: 0972-0820
DOI: 10.4103/0972-0820.161950